Yong jing xiang yong jing jie 160 taiwan12/6/2023 ![]() LTD LTP Synaptic plasticity comorbidity glutamatergic ligand-receptor posttraumatic stress disorder. The summarized function and mechanism of synaptic plasticity in PTSD and its comorbidities may help us further understand PTSD and provide insight into novel neuroplasticity modifying for diagnostics and treatment for PTSD. In this review, we mainly focus on discussing the biological function and mechanism for diagnostics and therapy of synaptic plasticity in PTSD and associated comorbidities, such as schizophrenia, depression, sleep disturbances and alcohol dependence, and further studying the molecular mechanisms of PTSD with a particular focus on the LTP/LTD, glutamatergic ligand-receptor systems, voltage-gated calcium channels (VGCCs) and brain-derived neurotrophic factor (BDNF)-tyrosine kinase B (TrkB). Thus, synaptic plasticity which is a dysfunction reported in neurodegenerative disorders may also be involved in posttraumatic stress disorder (PTSD), an anxiety and/or memory disorder developed after experiencing natural disasters, domestic violence or combat-related trauma. Authors:Ji, Min (1) Liu, Ling-Jie (1) Zhai, Hong-Yan (1) Liu, Jing (1). In general, the dysfunction of synaptic plasticity was involved in a wide spectrum of central nervous system (CNS) disorders, including some neurodegenerative disorders. Gao, Yun-Qiu (1, 2) Zhao, Jia-Yu (1, 2) Zhang, Zhen (1, 2) Hu, Yong-Bo (1. The process of synaptic connections playing a crucial role in improving cognitive processes is important to the processing of information in brain. ![]() ![]() See the complete profile on LinkedIn and discover JingJing’s connections and jobs at similar companies. JingJing has 3 jobs listed on their profile. The studying of synaptic plasticity, the ability of synaptic connections between neurons to be weakened or strengthened and specifically long-term potentiation (LTP) and long-term depression (LTD), is one of the most active areas of research in neuroscience. View JingJing Yong’s profile on LinkedIn, the world’s largest professional community.
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